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Defective Endogenous Pain Modulation in Fibromyalgia: A Meta-Analysis of Temporal Summation and Conditioned Pain Modulation Paradigms

Fibromyalgia (FM) is a complex chronic pain disease, characterized by generalized diffuse musculoskeletal pain.59,76 The worldwide prevalence of FM is estimated between 2% and 4%, and the U.S. incidence is estimated at 6.88 cases per 1,000 people per year for men and 11.28 cases per 1,000 people per year for women.59,71 Diagnosis is difficult, on the basis of clinical signs, and has no specific confirmatory test. As a result, in 1999 the American College of Rheumatology established that diagnosis required pain on digital palpation in 11 or more of 18 specific sites.

Defective Endogenous Pain Modulation in Fibromyalgia: A Meta-Analysis of Temporal Summation and Conditioned Pain Modulation Paradigms

Orginally Published At: Pain Journal

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