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Increased HCN Channel Activity in the Gasserian Ganglion Contributes to Trigeminal Neuropathic Pain

Orofacial pain is estimated to affect up to 7% of the general population.36 Chronic pain caused by trigeminal nerve damage is severe and more debilitating than other types of neuropathic pain.4 Furthermore, neuropathic pain associated with the trigeminal nerve system is more resistant to treatments.25,36 Studies have shown that pain caused by facial nerve injury has different physiological and pathological characteristics compared with pain induced by spinal nerve injury,2,20,21 possibly because of the anatomical and molecular differences between facial and body sensory pathways.

Increased HCN Channel Activity in the Gasserian Ganglion Contributes to Trigeminal Neuropathic Pain

Orginally Published At: Pain Journal

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