The Committees voted 12 to 5 that the drug should be labeled as an abuse-deterrent product by the nasal route of abuse, but they voted 10 to 7 that the drug should not be labeled as an abuse-deterrent product by the intravenous route of abuse.
FDA Panel Recommends Abuse-Deterrent Oxycodone Tablets
Chronic pain is associated with pathological changes in neuronal activity over somatosensory, insular, cingulate, and prefrontal cortices.46 These brain regions play a fundamental role in the processing of pain.32,51,57 Several electroencephalography (EEG) and magnetoencephalography (MEG) studies have shown that patients with chronic pain exhibit abnormal neuronal oscillations.43,55 In particular, pathologically increased theta oscillations (4-8Hz) 34,48,49,53,58 […]
A reduction in the functional connectivity between the sensorimotor cortex and the anterior cingulate cortex and dorsolateral prefrontal cortex may be associated with δ-9-tetrahydrocannabinol-associated analgesia in patients with chronic radicular neuropathic pain.
Altered Brain Connectivity Patterns Associated With THC-Induced Analgesia
Orginally Published At: Neuropathic Pain