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Is the Nociception Mechanism Altered in Offspring of Morphine-Abstinent Rats?

Family, twin, and adoption studies have yielded enormous amounts of valuable information about drug dependence as a multifactorial and polygenic disorder.30,32 Chronic drug exposure renders lasting molecular and cellular changes in the central nervous system including alternations in gene expression, mRNA level, protein level, and synaptic plasticity.39 Molecular as well as behavioral studies indicate that addictive substances induce long-lasting changes in the behavior and gene expression in some brain regions involved in reward circuit.

Is the Nociception Mechanism Altered in Offspring of Morphine-Abstinent Rats?

Orginally Published At: Pain Journal

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