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Neonatal Handling Produces Sex Hormone-Dependent Resilience to Stress-Induced Muscle Hyperalgesia in Rats

Chronic musculoskeletal pain, which is over-represented among women, is a common, debilitating and costly condition, which currently lacks effective treatment.58,61,66 Psychological stress is well established to contribute to the etiopathogenesis of chronic musculoskeletal pain,13,54,62 because it can trigger as well as aggravate these pain syndromes.24,54,62 Despite the importance of these 2 factors, the mechanisms underlying the interaction between sex and stress in chronic musculoskeletal pain remains poorly understood.

Neonatal Handling Produces Sex Hormone-Dependent Resilience to Stress-Induced Muscle Hyperalgesia in Rats

Orginally Published At: Pain Journal

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