Posted on

Opposing Roles of Estradiol and Testosterone on Stress-Induced Visceral Hypersensitivity in Rats

Women disproportionately suffer from chronic pain conditions including irritable bowel syndrome (IBS), fibromyalgia, migraine, and temporomandibular joint pain, many of which are comorbid with anxiety or depression disorders.7,9,11,29,37,110 During the past decades, efforts have been made to explore the mechanisms underlying sex differences in stress-induced anxiety and depression (for review, see Bangasser and Valentino8 and McEwen et al72). However, less is known about mechanisms underlying sex differences in stress-induced chronic pain conditions.

Opposing Roles of Estradiol and Testosterone on Stress-Induced Visceral Hypersensitivity in Rats

Orginally Published At: Pain Journal

Leave a Reply

Your email address will not be published. Required fields are marked *