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Oxidative stress contributes to fracture/cast-induced inflammation and pain in a rat model of complex regional pain syndrome

Complex regional pain syndrome (CRPS) develops after a range of injuries including fractures and soft tissue trauma to the extremities.43 The underlying mechanism of CRPS has not been fully elucidated and there are no specific medications approved for the treatment of CRPS. Oxidative stress results from an imbalance between ROS production and antioxidant defense systems. ROS have been implicated in many degenerative neurological conditions, such as Alzheimer’s disease1 and Parkinson’s disease18 and oxidative stress may also contribute to pain in various diseases, including fibromyalgia,26 diabetes,35,48 and CRPS.

Oxidative stress contributes to fracture/cast-induced inflammation and pain in a rat model of complex regional pain syndrome

Orginally Published At: Pain Journal

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