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Pharmacopuncture with Scolopendra subspinipes suppresses mechanical allodynia in oxaliplatin-induced neuropathic mice and potentiates clonidine-induced anti-allodynia without hypotension or motor impairment

Chemotherapy-induced neuropathic pain is a common dose-limiting side effect of anticancer drugs but lacks an effective treatment strategy. Scolopendra subspinipes (SS) has been used in traditional medicine to treat chronic neuronal diseases. Moreover, pharmacopuncture with SS (SSP) produces potent analgesia in humans and experimental animals. In this study, we examined the effect of SSP into the ST36 acupoint on oxaliplatin-induced mechanical allodynia in mice. Acupoint treatment with SSP (0.5%/20 μL) significantly reduced mechanical allodynia produced by a single oxaliplatin injection (10 mg/kg, i.p.), which was completely prevented by acupoint pre-injection of lidocaine.

Pharmacopuncture with Scolopendra subspinipes suppresses mechanical allodynia in oxaliplatin-induced neuropathic mice and potentiates clonidine-induced anti-allodynia without hypotension or motor impairment

Orginally Published At: Pain Journal

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