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Pupil Size Variation and Pain—Can the Results be Generalized?

I read with great interest the article by Charier et al,2 describing the increase in pupillary size variation (PSV) associated with labor pain. A method of objectively measuring pain has obvious and profound clinical applications. The hypothesis that pain and pupil size variation could be related is quite reasonable, because it has recently been shown that opioids decrease pupil size variation in healthy volunteers,1 and that pupil size variation predicts opioid efficacy in postoperative patients.

Pupil Size Variation and Pain—Can the Results be Generalized?

Orginally Published At: Pain Journal

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