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Oxidative stress contributes to fracture/cast-induced inflammation and pain in a rat model of complex regional pain syndrome

Complex regional pain syndrome (CRPS) develops after a range of injuries including fractures and soft tissue trauma to the extremities.43 The underlying mechanism of CRPS has not been fully elucidated and there are no specific medications approved for the treatment of CRPS. Oxidative stress results from an imbalance between ROS production and antioxidant defense systems. ROS have been implicated in many degenerative neurological conditions, such as Alzheimer’s disease1 and Parkinson’s disease18 and oxidative stress may also contribute to pain in various diseases, including fibromyalgia,26 diabetes,35,48 and CRPS.

Oxidative stress contributes to fracture/cast-induced inflammation and pain in a rat model of complex regional pain syndrome

Orginally Published At: Pain Journal

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No, stress is not your friend

Stress is your friend: this is the big idea of an extremely popular 2013 TED talk by Kelly McGonigal, and the book that inevitably followed it. Supposedly you are insulated from the health consequences of stress and anxiety if you just reframe it as a healthy response to a challenge. It’s nonsense on many levels, basically extravagant overinterpretation of a research artifact, as many critics have explained, but “a lie gets halfway around the world before truth puts on its boots.” McGonigal’s talk has become one of the classic examples of the empty sensationalism of so many TED talks.

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No, stress is not your friend


Orginally Published At: Pain Science

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“Adrenal fatigue” is not a thing

Adrenal fatigue was invented by a chiro so he could sell a cure. It is supposedly caused by chronic stress and “burnout” of the adrenal glands, and it’s a common bogus explanation (see Cadegiani et al) for fibromyalgia and chronic widespread pain. At best, that’s a simplistic guess; at worst, it’s a great way to peddle false hope to fibromyalgia patients.

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“Adrenal fatigue” is not a thing


Orginally Published At: Pain Science

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Catastrophizing, Solicitous Responses From Significant Others and Function in Individuals with Neuropathic Pain, Osteoarthritis or Spinal Pain in the General Population

Pain catastrophizing is associated with less psychological and physical function• Solicitous responding to pain is associated with less insomnia severity• A neuropathic pain diagnosis is associated with higher levels of insomnia severity• Neuropathic or spinal pain is associated with higher levels of psychological distress

Catastrophizing, Solicitous Responses From Significant Others and Function in Individuals with Neuropathic Pain, Osteoarthritis or Spinal Pain in the General Population

Orginally Published At: Pain Journal

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Chronic Pain, TBI, and PTSD in Military Veterans: A Link to Suicidal Ideation and Violent Impulses?

Approximately 50% of U.S. military veterans experience chronic pain, making it one of the most common health complaints among this population.3,44,71 Rates of chronic pain are particularly high for U.S. veterans of Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND).28,58 Chronic pain symptoms in this cohort are often comorbid with psychiatric conditions such as depression,64 substance use disorders,16 and posttraumatic stress disorder (PTSD). Chronic pain in U.S.

Chronic Pain, TBI, and PTSD in Military Veterans: A Link to Suicidal Ideation and Violent Impulses?

Orginally Published At: Pain Journal

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Opposing Roles of Estradiol and Testosterone on Stress-Induced Visceral Hypersensitivity in Rats

Women disproportionately suffer from chronic pain conditions including irritable bowel syndrome (IBS), fibromyalgia, migraine, and temporomandibular joint pain, many of which are comorbid with anxiety or depression disorders.7,9,11,29,37,110 During the past decades, efforts have been made to explore the mechanisms underlying sex differences in stress-induced anxiety and depression (for review, see Bangasser and Valentino8 and McEwen et al72). However, less is known about mechanisms underlying sex differences in stress-induced chronic pain conditions.

Opposing Roles of Estradiol and Testosterone on Stress-Induced Visceral Hypersensitivity in Rats

Orginally Published At: Pain Journal

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Randomized Controlled Trial of Online Acceptance and Commitment Therapy for Fibromyalgia

Fibromyalgia (FM) is a chronic pain disorder of uncertain etiology characterized by widespread pain and numerous potential comorbidities including fatigue, disordered sleep, neurocognitive deficits, gastrointestinal distress, headache, anxiety, and depression.61 This symptomatology often presents in an unpredictable remitting/relapsing cycle that further detracts from patients’ quality of life and results in significantly increased medical costs, health care utilization, and work-related disability.

Randomized Controlled Trial of Online Acceptance and Commitment Therapy for Fibromyalgia

Orginally Published At: Pain Journal

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The Psychometric Properties of the MBPS Scale Used to Assess Procedural Pain

The importance of assessing and managing procedural pain has gained increasing attention in recent years particularly as infants and children are frequently exposed to painful and distressing procedures as part of their health care. Although self-report is the accepted standard for pain assessment, infants and young children are developmentally unable to provide self-report. For this reason clinicians and researchers are reliant on proxy measures of pain intensity. Multidimensional observational pain scales have repeatedly been proposed as a viable option to support pain assessment in infants and children and >60 behavioral scales appear in the literature.

The Psychometric Properties of the MBPS Scale Used to Assess Procedural Pain

Orginally Published At: Pain Journal

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Neonatal Handling Produces Sex Hormone-Dependent Resilience to Stress-Induced Muscle Hyperalgesia in Rats

Chronic musculoskeletal pain, which is over-represented among women, is a common, debilitating and costly condition, which currently lacks effective treatment.58,61,66 Psychological stress is well established to contribute to the etiopathogenesis of chronic musculoskeletal pain,13,54,62 because it can trigger as well as aggravate these pain syndromes.24,54,62 Despite the importance of these 2 factors, the mechanisms underlying the interaction between sex and stress in chronic musculoskeletal pain remains poorly understood.

Neonatal Handling Produces Sex Hormone-Dependent Resilience to Stress-Induced Muscle Hyperalgesia in Rats

Orginally Published At: Pain Journal

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Daily Anxiety and Depressive Symptoms in Couples Coping With Vulvodynia: Associations With Women's Pain, Women's Sexual Function, and Both Partners' Sexual Distress

Vulvodynia is a common idiopathic gynecological pain condition. With a prevalence of 8 to 12% in the general population,32,33,60 provoked vestibulodynia (PVD) is the most common subtype and is characterized by a burning pain elicited upon pressure to the vulvar vestibule.7,14,30 This intermittent pain significantly disrupts couples’ sexuality.10,25,29,36,49,56 Controlled studies show that affected women report more sexual distress, poorer sexual function, and feelings of inadequacy as a sexual partner.

Daily Anxiety and Depressive Symptoms in Couples Coping With Vulvodynia: Associations With Women’s Pain, Women’s Sexual Function, and Both Partners’ Sexual Distress

Orginally Published At: Pain Journal