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The blind leading the not so blind: a meta-analysis of blinding in pharmacological trials for chronic pain

Randomised controlled trials (RCTs) are the cornerstone of evidence-based interventions both for chronic pain and medicine more generally. In particular, double-blind placebo-controlled RCTs have been heavily relied upon to determine treatment efficacy and safety of chronic pain interventions. Hundreds of double-blind placebo-controlled RCTs are run each year worldwide to test various interventions for chronic pain, with hundreds of thousands of people with chronic pain participating in these trials.

The blind leading the not so blind: a meta-analysis of blinding in pharmacological trials for chronic pain

Orginally Published At: Pain Journal

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