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The Rodent Tibia Fracture Model: A Critical Review and Comparison with the Complex Regional Pain Syndrome Literature

• This review compared a rodent tibia fracture model (TFM) to the CRPS literature• The TFM generated nociceptive and inflammatory symptoms resembling early CRPS• Neuropeptide signaling and cytokine expression are up-regulated after fracture• Fracture activated spinal glia and induced changes in brain dendritic architecture• B cell production of IgM autoantibodies also contributed to post fracture pain

The Rodent Tibia Fracture Model: A Critical Review and Comparison with the Complex Regional Pain Syndrome Literature

Orginally Published At: Pain Journal

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